We studied the prevalence, type and associated features of monoclonal gammopathy in patients with systemic lupus erythematosus sle. Monoclonal gammopathy of undetermined significance mgus is a premalignant plasma cell dyscrasia that consistently precedes multiple myeloma mm with a 1% risk of progression per year. Neurological symptoms caused by the monoclonal immunoglobulins or free lightchains are often associated with a high morbidity. Monoclonal gammopathy of undetermined significance mgus including immunoglobulin light chain only mgus is an age dependent premalignant tumor that is present in about 4% of caucasian individuals over the age of 50, but is comprised of two different kinds of tumors, about 15% lymphoid or lymphoplasmacytoid mgus and the remainder plasma cell mgus. Pathogenesis of monoclonal gammopathy of undetermined. Normann steiner 1, angelika schwarzler, georg gobel 3, wolfgang loscher 2, julia. Disease associations with monoclonal gammopathy of. Prior autoimmune disease and risk of monoclonal gammopathy.
The group includes a severe autosomal recessive form chondrodysplasia punctata, rhizomelic, an autosomal dominant form conradihunermann syndrome, and a milder xlinked form. Article pdf available in oncotarget 83 december 2016 with 87 reads how we measure reads. Monoclonal gammopathy of undetermined significance mgus. Pdf monoclonal gammopathy of undetermined significance. Hemoglobin f hbf contains two globin alpha chains and two globin gamma chains.
Prognostic impact of serum heavylight chain pairs in patients with monoclonal gammopathy of undetermined. Monoclonal gammopathy of undetermined significance mgus is the most common plasma cell disorder, occurring in 3% of the population older than 50 years. Patients included in the university of toronto lupus database. Are neurological complications of monoclonal gammopathy of undetermined significance underestimated. Several observational studies have investigated autoimmune disease and subsequent risk of monoclonal gammopathy of undetermined significance mgus and multiple myeloma.
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